Th17 Polarization under Hypoxia Results in Increased IL-10 Production in a Pathogen-Independent Manner

The IL-17-producing CD4(+) T helper cell (Th17) differentiation is affected by stimulation of the aryl hydrocarbon receptor (AhR) pathway and by hypoxia-inducible factor 1 alpha (HIF-1α). In some cases, Th17 become non-pathogenic and produce IL-10. However, the initiating events triggering this phen...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Volchenkov, Roman, Nygaard, Vegard, Sener, Zeynep, Skålhegg, Bjørn Steen
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474482/
https://ncbi.nlm.nih.gov/pubmed/28674533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00698
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