Transcriptional mechanisms of resistance to anti-PD-1 therapy

PURPOSE: To explore factors associated with response and resistance to anti-PD-1 therapy, we analyzed multiple disease sites at autopsy in a patient with widely metastatic melanoma who had a heterogeneous response. MATERIALS AND METHODS: Twenty-six melanoma specimens (four pre-mortem, 22 post-mortem...

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Publicado en:Clin Cancer Res
Autores principales: Ascierto, Maria L., Makohon-Moore, Alvin, Lipson, Evan J., Taube, Janis M., McMiller, Tracee L., Berger, Alan E., Fan, Jinshui, Kaunitz, Genevieve J., Cottrell, Tricia R., Kohutek, Zachary A., Favorov, Alexander, Makarov, Vladimir, Riaz, Nadeem, Chan, Timothy A., Cope, Leslie, Hruban, Ralph H., Pardoll, Drew M., Taylor, Barry S., Solit, David B., Iacobuzio-Donahue, Christine A, Topalian, Suzanne L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474192/
https://ncbi.nlm.nih.gov/pubmed/28193624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-0270
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