Transcriptional mechanisms of resistance to anti-PD-1 therapy

PURPOSE: To explore factors associated with response and resistance to anti-PD-1 therapy, we analyzed multiple disease sites at autopsy in a patient with widely metastatic melanoma who had a heterogeneous response. MATERIALS AND METHODS: Twenty-six melanoma specimens (four pre-mortem, 22 post-mortem...

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Vydáno v:Clin Cancer Res
Hlavní autoři: Ascierto, Maria L., Makohon-Moore, Alvin, Lipson, Evan J., Taube, Janis M., McMiller, Tracee L., Berger, Alan E., Fan, Jinshui, Kaunitz, Genevieve J., Cottrell, Tricia R., Kohutek, Zachary A., Favorov, Alexander, Makarov, Vladimir, Riaz, Nadeem, Chan, Timothy A., Cope, Leslie, Hruban, Ralph H., Pardoll, Drew M., Taylor, Barry S., Solit, David B., Iacobuzio-Donahue, Christine A, Topalian, Suzanne L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474192/
https://ncbi.nlm.nih.gov/pubmed/28193624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-0270
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