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Transcriptional mechanisms of resistance to anti-PD-1 therapy

PURPOSE: To explore factors associated with response and resistance to anti-PD-1 therapy, we analyzed multiple disease sites at autopsy in a patient with widely metastatic melanoma who had a heterogeneous response. MATERIALS AND METHODS: Twenty-six melanoma specimens (four pre-mortem, 22 post-mortem...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Ascierto, Maria L., Makohon-Moore, Alvin, Lipson, Evan J., Taube, Janis M., McMiller, Tracee L., Berger, Alan E., Fan, Jinshui, Kaunitz, Genevieve J., Cottrell, Tricia R., Kohutek, Zachary A., Favorov, Alexander, Makarov, Vladimir, Riaz, Nadeem, Chan, Timothy A., Cope, Leslie, Hruban, Ralph H., Pardoll, Drew M., Taylor, Barry S., Solit, David B., Iacobuzio-Donahue, Christine A, Topalian, Suzanne L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474192/
https://ncbi.nlm.nih.gov/pubmed/28193624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-0270
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