Allelic Variation in the Toll-Like Receptor Adaptor Protein Ticam2 Contributes to SARS-Coronavirus Pathogenesis in Mice

Host genetic variation is known to contribute to differential pathogenesis following infection. Mouse models allow direct assessment of host genetic factors responsible for susceptibility to Severe Acute Respiratory Syndrome coronavirus (SARS-CoV). Based on an assessment of early stage lines from th...

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Dettagli Bibliografici
Pubblicato in:G3 (Bethesda)
Autori principali: Gralinski, Lisa E., Menachery, Vineet D., Morgan, Andrew P., Totura, Allison L., Beall, Anne, Kocher, Jacob, Plante, Jessica, Harrison-Shostak, D. Corinne, Schäfer, Alexandra, Pardo-Manuel de Villena, Fernando, Ferris, Martin T., Baric, Ralph S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Genetics Society of America 2017
Soggetti:
Multiparental Populations
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5473747/
https://ncbi.nlm.nih.gov/pubmed/28592648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.117.041434
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