Pleiotropic Effects of Trait-Associated Genetic Variation on DNA Methylation: Utility for Refining GWAS Loci

Most genetic variants identified in genome-wide association studies (GWASs) of complex traits are thought to act by affecting gene regulation rather than directly altering the protein product. As a consequence, the actual genes involved in disease are not necessarily the most proximal to the associa...

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發表在:Am J Hum Genet
Main Authors: Hannon, Eilis, Weedon, Mike, Bray, Nicholas, O’Donovan, Michael, Mill, Jonathan
格式: Artigo
語言:Inglês
出版: Elsevier 2017
主題:
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5473725/
https://ncbi.nlm.nih.gov/pubmed/28528868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2017.04.013
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