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Pleiotropic Effects of Trait-Associated Genetic Variation on DNA Methylation: Utility for Refining GWAS Loci
Most genetic variants identified in genome-wide association studies (GWASs) of complex traits are thought to act by affecting gene regulation rather than directly altering the protein product. As a consequence, the actual genes involved in disease are not necessarily the most proximal to the associa...
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Publicado no: | Am J Hum Genet |
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Main Authors: | , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Elsevier
2017
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5473725/ https://ncbi.nlm.nih.gov/pubmed/28528868 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2017.04.013 |
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