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Human LACC1 increases innate receptor-induced responses and a LACC1 disease-risk variant modulates these outcomes

Functional consequences for most inflammatory disease-associated loci are incompletely defined, including in the LACC1 (C13orf31) region. Here we show that human peripheral and intestinal myeloid-derived cells express laccase domain-containing 1 (LACC1); LACC1 is expressed in both the cytoplasm and...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Lahiri, Amit, Hedl, Matija, Yan, Jie, Abraham, Clara
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5472760/
https://ncbi.nlm.nih.gov/pubmed/28593945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15614
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