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IRF5 and IRF5 Disease-Risk Variants Increase Glycolysis and Human M1 polarization By Regulating Proximal Signaling and Akt2 Activation
Interferon regulatory factor 5 (IRF5) regulates inflammatory M1 macrophage polarization, and disease-associated IRF5 genetic variants regulate pattern-recognition-receptor (PRR)-induced cytokines. PRR-stimulated macrophages and M1 macrophages exhibit enhanced glycolysis, a central mediator of inflam...
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| Publicado no: | Cell Rep |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5165654/ https://ncbi.nlm.nih.gov/pubmed/27545875 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.07.060 |
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