Precise Manipulation of Chromosomes in Vivo Enables Genome-Wide Codon Replacement

We present genome engineering technologies that are capable of fundamentally reengineering genomes from the nucleotide to the megabase scale. We used multiplex automated genome engineering (MAGE) to site-specifically replace all 314 TAG stop codons with synonymous TAA codons in parallel across 32 Es...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Science
Main Authors: Isaacs, Farren J., Carr, Peter A., Wang, Harris H., Lajoie, Marc J., Sterling, Bram, Kraal, Laurens, Tolonen, Andrew C., Gianoulis, Tara A., Goodman, Daniel B., Reppas, Nikos B., Emig, Christopher J., Bang, Duhee, Hwang, Samuel J., Jewett, Michael C., Jacobson, Joseph M., Church, George M.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5472332/
https://ncbi.nlm.nih.gov/pubmed/21764749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1205822
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker