Human CTP synthase filament structure reveals the active enzyme conformation

The universally conserved enzyme CTP synthase (CTPS) forms filaments in bacteria and eukaryotes. In bacteria polymerization inhibits CTPS activity and is required for nucleotide homeostasis. Here we show that human CTPS polymerization increases catalytic activity. The cryoEM structures of bacterial...

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Pubblicato in:Nat Struct Mol Biol
Autori principali: Lynch, Eric M., Hicks, Derrick R., Shepherd, Matthew, Endrizzi, James A., Maker, Allison, Hansen, Jesse M., Barry, Rachael M., Gitai, Zemer, Baldwin, Enoch P., Kollman, Justin M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5472220/
https://ncbi.nlm.nih.gov/pubmed/28459447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3407
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