Inhibition of Escherichia coli CTP Synthetase by NADH and Other Nicotinamides and Their Mutual Interactions with CTP and GTP

CTP synthetases catalyze the last step of pyrimidine biosynthesis and provide the sole de novo source of cytosine-containing nucleotides. As a central regulatory hub, they are regulated by ribonucleotide and enzyme concentration through ATP and UTP substrate availability, CTP product inhibition, GTP...

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Vydáno v:Biochemistry
Hlavní autoři: Habrian, Chris, Chandrasekhara, Adithi, Shahrvini, Bita, Hua, Brian, Lee, Jason, Jesinghaus, Roger, Barry, Rachael, Gitai, Zemer, Kollman, Justin, Baldwin, Enoch P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5584805/
https://ncbi.nlm.nih.gov/pubmed/27571563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00383
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