Large-scale filament formation inhibits the activity of CTP synthetase

CTP Synthetase (CtpS) is a universally conserved and essential metabolic enzyme. While many enzymes form small oligomers, CtpS forms large-scale filamentous structures of unknown function in prokaryotes and eukaryotes. By simultaneously monitoring CtpS polymerization and enzymatic activity, we show...

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Bibliographische Detailangaben
Hauptverfasser: Barry, Rachael M, Bitbol, Anne-Florence, Lorestani, Alexander, Charles, Emeric J, Habrian, Chris H, Hansen, Jesse M, Li, Hsin-Jung, Baldwin, Enoch P, Wingreen, Ned S, Kollman, Justin M, Gitai, Zemer
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2014
Schlagworte:
Biochemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4126345/
https://ncbi.nlm.nih.gov/pubmed/25030911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.03638
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