Human CTP synthase filament structure reveals the active enzyme conformation

The universally conserved enzyme CTP synthase (CTPS) forms filaments in bacteria and eukaryotes. In bacteria polymerization inhibits CTPS activity and is required for nucleotide homeostasis. Here we show that human CTPS polymerization increases catalytic activity. The cryoEM structures of bacterial...

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Detalhes bibliográficos
Publicado no:Nat Struct Mol Biol
Main Authors: Lynch, Eric M., Hicks, Derrick R., Shepherd, Matthew, Endrizzi, James A., Maker, Allison, Hansen, Jesse M., Barry, Rachael M., Gitai, Zemer, Baldwin, Enoch P., Kollman, Justin M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5472220/
https://ncbi.nlm.nih.gov/pubmed/28459447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3407
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