Recent Developments Using Small Molecules to Target RAD51: How to Best Modulate RAD51 for Anticancer Therapy?

Homologous recombination (HR) is an evolutionarily conserved DNA repair process. Overexpression of the key HR protein RAD51 is a common feature of malignant cells. RAD51 plays two distinct genome-stabilizing roles, including HR-mediated repair of double-strand breaks (DSBs) and the promotion of repl...

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Bibliographic Details
Published in:ChemMedChem
Main Authors: Budke, Brian, Lv, Wei, Kozikowski, Alan P., Connell, Philip P.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5472043/
https://ncbi.nlm.nih.gov/pubmed/27781374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201600426
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