Laddar...
A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death
BRCA2 controls RAD51 recombinase during homologous DNA recombination (HDR) through eight evolutionarily conserved BRC repeats, which individually engage RAD51 via the motif Phe-x-x-Ala. Using structure-guided molecular design, templated on a monomeric thermostable chimera between human RAD51 and arc...
Sparad:
| I publikationen: | Cell Chem Biol |
|---|---|
| Huvudupphovsmän: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Cell Press
2021
|
| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8219027/ https://ncbi.nlm.nih.gov/pubmed/33662256 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2021.02.006 |
| Taggar: |
Lägg till en tagg
Inga taggar, Lägg till första taggen!
|