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Small-Molecule Inhibitors That Target Protein–Protein Interactions in the RAD51 Family of Recombinases
The development of small molecules that inhibit protein–protein interactions continues to be a challenge in chemical biology and drug discovery. Herein we report the development of indole-based fragments that bind in a shallow surface pocket of a humanised surrogate of RAD51. RAD51 is an ATP-depende...
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| Publicat a: | ChemMedChem |
|---|---|
| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
WILEY-VCH Verlag
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4506530/ https://ncbi.nlm.nih.gov/pubmed/25470112 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201402428 |
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