Novel selective β(1)-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease

β-Blockers reduce mortality and improve symptoms in people with heart disease; however, current clinically available β-blockers have poor selectivity for the cardiac β(1)-adrenoceptor (AR) over the lung β(2)-AR. Unwanted β(2)-blockade risks causing life-threatening bronchospasm and reduced efficacy...

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Bibliographic Details
Published in:	FASEB J
Main Authors:	Baker, Jillian G., Gardiner, Sheila M., Woolard, Jeanette, Fromont, Christophe, Jadhav, Gopal P., Mistry, Shailesh N., Thompson, Kevin S. J., Kellam, Barrie, Hill, Stephen J., Fischer, Peter M.
Format:	Artigo
Language:	Inglês
Published:	Federation of American Societies for Experimental Biology 2017
Subjects:	Research
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5471521/ https://ncbi.nlm.nih.gov/pubmed/28400472 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201601305R
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Novel selective β(1)-adrenoceptor antagonists for concomitant cardiovascular and respiratory disease

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