Diagnostic Yield of Clinical Tumor and Germline Whole-Exome Sequencing for Children With Solid Tumors

IMPORTANCE: Whole-exome sequencing (WES) has the potential to reveal tumor and germline mutations of clinical relevance, but the diagnostic yield for pediatric patients with solid tumors is unknown. OBJECTIVE: To characterize the diagnostic yield of combined tumor and germline WES for children with...

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Detalhes bibliográficos
Publicado no:JAMA Oncol
Main Authors: Parsons, D. Williams, Roy, Angshumoy, Yang, Yaping, Wang, Tao, Scollon, Sarah, Bergstrom, Katie, Kerstein, Robin A., Gutierrez, Stephanie, Petersen, Andrea K., Bavle, Abhishek, Lin, Frank Y., López-Terrada, Dolores H., Monzon, Federico A., Hicks, M. John, Eldin, Karen W., Quintanilla, Norma M., Adesina, Adekunle M., Mohila, Carrie A., Whitehead, William, Jea, Andrew, Vasudevan, Sanjeev A., Nuchtern, Jed G., Ramamurthy, Uma, McGuire, Amy L., Hilsenbeck, Susan G., Reid, Jeffrey G., Muzny, Donna M., Wheeler, David A., Berg, Stacey L., Chintagumpala, Murali M., Eng, Christine M., Gibbs, Richard A., Plon, Sharon E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5471125/
https://ncbi.nlm.nih.gov/pubmed/26822237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2015.5699
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