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Diagnostic Yield of Clinical Tumor and Germline Whole-Exome Sequencing for Children With Solid Tumors

IMPORTANCE: Whole-exome sequencing (WES) has the potential to reveal tumor and germline mutations of clinical relevance, but the diagnostic yield for pediatric patients with solid tumors is unknown. OBJECTIVE: To characterize the diagnostic yield of combined tumor and germline WES for children with...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:JAMA Oncol
मुख्य लेखकों: Parsons, D. Williams, Roy, Angshumoy, Yang, Yaping, Wang, Tao, Scollon, Sarah, Bergstrom, Katie, Kerstein, Robin A., Gutierrez, Stephanie, Petersen, Andrea K., Bavle, Abhishek, Lin, Frank Y., López-Terrada, Dolores H., Monzon, Federico A., Hicks, M. John, Eldin, Karen W., Quintanilla, Norma M., Adesina, Adekunle M., Mohila, Carrie A., Whitehead, William, Jea, Andrew, Vasudevan, Sanjeev A., Nuchtern, Jed G., Ramamurthy, Uma, McGuire, Amy L., Hilsenbeck, Susan G., Reid, Jeffrey G., Muzny, Donna M., Wheeler, David A., Berg, Stacey L., Chintagumpala, Murali M., Eng, Christine M., Gibbs, Richard A., Plon, Sharon E.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2016
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5471125/
https://ncbi.nlm.nih.gov/pubmed/26822237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2015.5699
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