Diagnostic Yield of Clinical Tumor and Germline Whole-Exome Sequencing for Children With Solid Tumors

IMPORTANCE: Whole-exome sequencing (WES) has the potential to reveal tumor and germline mutations of clinical relevance, but the diagnostic yield for pediatric patients with solid tumors is unknown. OBJECTIVE: To characterize the diagnostic yield of combined tumor and germline WES for children with...

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Publié dans:JAMA Oncol
Auteurs principaux: Parsons, D. Williams, Roy, Angshumoy, Yang, Yaping, Wang, Tao, Scollon, Sarah, Bergstrom, Katie, Kerstein, Robin A., Gutierrez, Stephanie, Petersen, Andrea K., Bavle, Abhishek, Lin, Frank Y., López-Terrada, Dolores H., Monzon, Federico A., Hicks, M. John, Eldin, Karen W., Quintanilla, Norma M., Adesina, Adekunle M., Mohila, Carrie A., Whitehead, William, Jea, Andrew, Vasudevan, Sanjeev A., Nuchtern, Jed G., Ramamurthy, Uma, McGuire, Amy L., Hilsenbeck, Susan G., Reid, Jeffrey G., Muzny, Donna M., Wheeler, David A., Berg, Stacey L., Chintagumpala, Murali M., Eng, Christine M., Gibbs, Richard A., Plon, Sharon E.
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5471125/
https://ncbi.nlm.nih.gov/pubmed/26822237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2015.5699
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