Dnmt3a-mediated inhibition of Wnt in cardiac progenitor cells improves differentiation and remote remodeling after infarction

Adult cardiac progenitor cells (CPCs) display a low capacity to differentiate into cardiomyocytes in injured hearts, strongly limiting the regenerative capacity of the mammalian myocardium. To identify new mechanisms regulating CPC differentiation, we used primary and clonally expanded Sca-1(+) CPCs...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: De Pauw, Aurelia, Andre, Emilie, Sekkali, Belaid, Bouzin, Caroline, Esfahani, Hrag, Barbier, Nicolas, Loriot, Axelle, De Smet, Charles, Vanhoutte, Laetitia, Moniotte, Stéphane, Gerber, Bernhard, di Mauro, Vittoria, Catalucci, Daniele, Feron, Olivier, Hilfiker-Kleiner, Denise, Balligand, Jean-Luc
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5470891/
https://ncbi.nlm.nih.gov/pubmed/28614798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.91810
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