Dnmt3a-mediated inhibition of Wnt in cardiac progenitor cells improves differentiation and remote remodeling after infarction

Adult cardiac progenitor cells (CPCs) display a low capacity to differentiate into cardiomyocytes in injured hearts, strongly limiting the regenerative capacity of the mammalian myocardium. To identify new mechanisms regulating CPC differentiation, we used primary and clonally expanded Sca-1(+) CPCs...

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Bibliografiske detaljer
Udgivet i:JCI Insight
Main Authors: De Pauw, Aurelia, Andre, Emilie, Sekkali, Belaid, Bouzin, Caroline, Esfahani, Hrag, Barbier, Nicolas, Loriot, Axelle, De Smet, Charles, Vanhoutte, Laetitia, Moniotte, Stéphane, Gerber, Bernhard, di Mauro, Vittoria, Catalucci, Daniele, Feron, Olivier, Hilfiker-Kleiner, Denise, Balligand, Jean-Luc
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5470891/
https://ncbi.nlm.nih.gov/pubmed/28614798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.91810
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