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Deep-sequencing of Marburg virus genome during sequential mouse passaging and cell-culture adaptation reveals extensive changes over time

Marburg virus (MARV) has caused outbreaks of filoviral hemorrhagic fever since its discovery in 1967. The largest and deadliest outbreak occurred in Angola in 2005, with 252 cases and 227 deaths. In 2014, we developed a mouse-adapted MARV, Angola variant through serial passaging in mice. The mouse-a...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Sci Rep
Κύριοι συγγραφείς: Wei, Haiyan, Audet, Jonathan, Wong, Gary, He, Shihua, Huang, Xueyong, Cutts, Todd, Theriault, Steven, Xu, Bianli, Kobinger, Gary, Qiu, Xiangguo
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Nature Publishing Group UK 2017
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5469859/
https://ncbi.nlm.nih.gov/pubmed/28611428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03318-3
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