Deep-sequencing of Marburg virus genome during sequential mouse passaging and cell-culture adaptation reveals extensive changes over time

Marburg virus (MARV) has caused outbreaks of filoviral hemorrhagic fever since its discovery in 1967. The largest and deadliest outbreak occurred in Angola in 2005, with 252 cases and 227 deaths. In 2014, we developed a mouse-adapted MARV, Angola variant through serial passaging in mice. The mouse-a...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Wei, Haiyan, Audet, Jonathan, Wong, Gary, He, Shihua, Huang, Xueyong, Cutts, Todd, Theriault, Steven, Xu, Bianli, Kobinger, Gary, Qiu, Xiangguo
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5469859/
https://ncbi.nlm.nih.gov/pubmed/28611428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03318-3
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