Deep-sequencing of Marburg virus genome during sequential mouse passaging and cell-culture adaptation reveals extensive changes over time

Marburg virus (MARV) has caused outbreaks of filoviral hemorrhagic fever since its discovery in 1967. The largest and deadliest outbreak occurred in Angola in 2005, with 252 cases and 227 deaths. In 2014, we developed a mouse-adapted MARV, Angola variant through serial passaging in mice. The mouse-a...

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Published in:Sci Rep
Main Authors: Wei, Haiyan, Audet, Jonathan, Wong, Gary, He, Shihua, Huang, Xueyong, Cutts, Todd, Theriault, Steven, Xu, Bianli, Kobinger, Gary, Qiu, Xiangguo
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5469859/
https://ncbi.nlm.nih.gov/pubmed/28611428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03318-3
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