Smart pH-sensitive nanoassemblies with cleavable PEGylation for tumor targeted drug delivery

A new acidly sensitive PEGylated polyethylenimine linked by Schiff base (PEG-s-PEI) was designed to render pH-sensitive PEGylation nanoassemblies through multiple interactions with indomethacin and docetaxel (DTX). DTX nanoassemblies driven by PEG-s-PEI thus formulated exhibited an excellent pH-sens...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Zhao, Guanren, Long, Ling, Zhang, Lina, Peng, Mingli, Cui, Ting, Wen, Xiaoxun, Zhou, Xing, Sun, Lijun, Che, Ling
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5469818/
https://ncbi.nlm.nih.gov/pubmed/28611459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03111-2
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