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Microglia limit the expansion of β-amyloid plaques in a mouse model of Alzheimer’s disease

BACKGROUND: Microglia are known as resident immune cells in the brain. β-amyloid (Aβ) plaques in the brain of Alzheimer’s disease (AD) are surrounded by microglia, but whether and how microglia affect the formation and maintenance of plaques remains controversial. METHODS: We depleted microglia by i...

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Détails bibliographiques
Publié dans:Mol Neurodegener
Auteurs principaux: Zhao, Ruohe, Hu, Wanling, Tsai, Julia, Li, Wei, Gan, Wen-Biao
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2017
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5468952/
https://ncbi.nlm.nih.gov/pubmed/28606182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0188-6
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