Selective lowering of synapsins induced by oligomeric α-synuclein exacerbates memory deficits

Mounting evidence indicates that soluble oligomeric forms of amyloid proteins linked to neurodegenerative disorders, such as amyloid-β (Aβ), tau, or α-synuclein (αSyn) might be the major deleterious species for neuronal function in these diseases. Here, we found an abnormal accumulation of oligomeri...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Larson, Megan E., Greimel, Susan J., Amar, Fatou, LaCroix, Michael, Boyle, Gabriel, Sherman, Mathew A., Schley, Hallie, Miel, Camille, Schneider, Julie A., Kayed, Rakez, Benfenati, Fabio, Lee, Michael K., Bennett, David A., Lesné, Sylvain E.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2017
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5468636/
https://ncbi.nlm.nih.gov/pubmed/28533388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704698114
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