Selective lowering of synapsins induced by oligomeric α-synuclein exacerbates memory deficits

Mounting evidence indicates that soluble oligomeric forms of amyloid proteins linked to neurodegenerative disorders, such as amyloid-β (Aβ), tau, or α-synuclein (αSyn) might be the major deleterious species for neuronal function in these diseases. Here, we found an abnormal accumulation of oligomeri...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Larson, Megan E., Greimel, Susan J., Amar, Fatou, LaCroix, Michael, Boyle, Gabriel, Sherman, Mathew A., Schley, Hallie, Miel, Camille, Schneider, Julie A., Kayed, Rakez, Benfenati, Fabio, Lee, Michael K., Bennett, David A., Lesné, Sylvain E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2017
Ábhair:
PNAS Plus
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5468636/
https://ncbi.nlm.nih.gov/pubmed/28533388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704698114
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