Selective lowering of synapsins induced by oligomeric α-synuclein exacerbates memory deficits

Mounting evidence indicates that soluble oligomeric forms of amyloid proteins linked to neurodegenerative disorders, such as amyloid-β (Aβ), tau, or α-synuclein (αSyn) might be the major deleterious species for neuronal function in these diseases. Here, we found an abnormal accumulation of oligomeri...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Larson, Megan E., Greimel, Susan J., Amar, Fatou, LaCroix, Michael, Boyle, Gabriel, Sherman, Mathew A., Schley, Hallie, Miel, Camille, Schneider, Julie A., Kayed, Rakez, Benfenati, Fabio, Lee, Michael K., Bennett, David A., Lesné, Sylvain E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5468636/
https://ncbi.nlm.nih.gov/pubmed/28533388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704698114
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