The Complex PrP(c)-Fyn Couples Human Oligomeric Aβ with Pathological Tau Changes in Alzheimer's Disease

Amid controversy, the cellular form of the prion protein PrP(c) has been proposed to mediate oligomeric amyloid-β (Aβ)-induced deficits. In contrast, there is consistent evidence that the Src kinase Fyn is activated by Aβ oligomers and leads to synaptic and cognitive impairment in transgenic animals...

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Autores principales: Larson, Megan, Sherman, Mathew A., Amar, Fatou, Nuvolone, Mario, Schneider, Julie A., Bennett, David A., Aguzzi, Adriano, Lesné, Sylvain E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2012
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568961/
https://ncbi.nlm.nih.gov/pubmed/23175838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1858-12.2012
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