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The Complex PrP(c)-Fyn Couples Human Oligomeric Aβ with Pathological Tau Changes in Alzheimer's Disease
Amid controversy, the cellular form of the prion protein PrP(c) has been proposed to mediate oligomeric amyloid-β (Aβ)-induced deficits. In contrast, there is consistent evidence that the Src kinase Fyn is activated by Aβ oligomers and leads to synaptic and cognitive impairment in transgenic animals...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Society for Neuroscience
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3568961/ https://ncbi.nlm.nih.gov/pubmed/23175838 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1858-12.2012 |
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