Soluble Conformers of Aβ and Tau Alter Selective Proteins Governing Axonal Transport

Despite the demonstration that amyloid-β (Aβ) can trigger increased tau phosphorylation and neurofibrillary tangle (NFT) formation in vivo, the molecular link associating Aβ and tau pathologies remains ill defined. Here, we observed that exposure of cultured primary neurons to Aβ trimers isolated fr...

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Publicat a:J Neurosci
Autors principals: Sherman, Mathew A., LaCroix, Michael, Amar, Fatou, Larson, Megan E., Forster, Colleen, Aguzzi, Adriano, Bennett, David A., Ramsden, Martin, Lesné, Sylvain E.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2016
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5039246/
https://ncbi.nlm.nih.gov/pubmed/27629715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1899-16.2016
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