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Substrate-Translocating Loops Regulate the Mechanochemical Coupling and Power Production in a AAA+ Protease
ATP-dependent proteases of the AAA+ family, including Escherichia coli ClpXP and the eukaryotic proteasome, contribute to maintenance of cellular proteostasis. ClpXP unfolds and translocates its substrates into an internal degradation chamber using cycles of alternating dwell and burst phases. The C...
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| Publicado no: | Nat Struct Mol Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5467750/ https://ncbi.nlm.nih.gov/pubmed/27669037 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3298 |
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