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Knots can impair protein degradation by ATP-dependent proteases

ATP-dependent proteases translocate proteins through a narrow pore for their controlled destruction. However, how a protein substrate containing a knotted topology affects this process remains unknown. Here, we characterized the effects of the trefoil-knotted protein MJ0366 from Methanocaldococcus j...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: San Martín, Álvaro, Rodriguez-Aliaga, Piere, Molina, José Alejandro, Martin, Andreas, Bustamante, Carlos, Baez, Mauricio
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5604015/
https://ncbi.nlm.nih.gov/pubmed/28847957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705916114
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