Misfolded polypeptides are selectively recognized and transported toward aggresomes by a CED complex

Misfolded polypeptides are rapidly cleared from cells via the ubiquitin–proteasome system (UPS). However, when the UPS is impaired, misfolded polypeptides form small cytoplasmic aggregates, which are sequestered into an aggresome and ultimately degraded by aggrephagy. Despite the relevance of the ag...

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Publicat a:Nat Commun
Autors principals: Park, Joori, Park, Yeonkyoung, Ryu, Incheol, Choi, Mi-Hyun, Lee, Hyo Jin, Oh, Nara, Kim, Kyutae, Kim, Kyoung Mi, Choe, Junho, Lee, Cheolju, Baik, Ja-Hyun, Kim, Yoon Ki
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5467238/
https://ncbi.nlm.nih.gov/pubmed/28589942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15730
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