Misfolded polypeptides are selectively recognized and transported toward aggresomes by a CED complex

Misfolded polypeptides are rapidly cleared from cells via the ubiquitin–proteasome system (UPS). However, when the UPS is impaired, misfolded polypeptides form small cytoplasmic aggregates, which are sequestered into an aggresome and ultimately degraded by aggrephagy. Despite the relevance of the ag...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Park, Joori, Park, Yeonkyoung, Ryu, Incheol, Choi, Mi-Hyun, Lee, Hyo Jin, Oh, Nara, Kim, Kyutae, Kim, Kyoung Mi, Choe, Junho, Lee, Cheolju, Baik, Ja-Hyun, Kim, Yoon Ki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5467238/
https://ncbi.nlm.nih.gov/pubmed/28589942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15730
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