Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase

A paucity of novel acting antibacterials is in development to treat the rising threat of antimicrobial resistance, particularly in Gram-negative hospital pathogens, which has led to renewed efforts in antibiotic drug discovery. Fluoroquinolones are broad-spectrum antibacterials that target DNA gyras...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Chan, Pan F., Germe, Thomas, Bax, Benjamin D., Huang, Jianzhong, Thalji, Reema K., Bacqué, Eric, Checchia, Anna, Chen, Dongzhao, Cui, Haifeng, Ding, Xiao, Ingraham, Karen, McCloskey, Lynn, Raha, Kaushik, Srikannathasan, Velupillai, Maxwell, Anthony, Stavenger, Robert A.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2017
Materias:
PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5465892/
https://ncbi.nlm.nih.gov/pubmed/28507124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700721114
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