Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase

A paucity of novel acting antibacterials is in development to treat the rising threat of antimicrobial resistance, particularly in Gram-negative hospital pathogens, which has led to renewed efforts in antibiotic drug discovery. Fluoroquinolones are broad-spectrum antibacterials that target DNA gyras...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Chan, Pan F., Germe, Thomas, Bax, Benjamin D., Huang, Jianzhong, Thalji, Reema K., Bacqué, Eric, Checchia, Anna, Chen, Dongzhao, Cui, Haifeng, Ding, Xiao, Ingraham, Karen, McCloskey, Lynn, Raha, Kaushik, Srikannathasan, Velupillai, Maxwell, Anthony, Stavenger, Robert A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2017
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PNAS Plus
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5465892/
https://ncbi.nlm.nih.gov/pubmed/28507124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700721114
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