Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase

A paucity of novel acting antibacterials is in development to treat the rising threat of antimicrobial resistance, particularly in Gram-negative hospital pathogens, which has led to renewed efforts in antibiotic drug discovery. Fluoroquinolones are broad-spectrum antibacterials that target DNA gyras...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Chan, Pan F., Germe, Thomas, Bax, Benjamin D., Huang, Jianzhong, Thalji, Reema K., Bacqué, Eric, Checchia, Anna, Chen, Dongzhao, Cui, Haifeng, Ding, Xiao, Ingraham, Karen, McCloskey, Lynn, Raha, Kaushik, Srikannathasan, Velupillai, Maxwell, Anthony, Stavenger, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5465892/
https://ncbi.nlm.nih.gov/pubmed/28507124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1700721114
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