Crystallization and initial crystallographic analysis of covalent DNA-cleavage complexes of Staphyloccocus aureus DNA gyrase with QPT-1, moxifloxacin and etoposide

Fluoroquinolone drugs such as moxifloxacin kill bacteria by stabilizing the normally transient double-stranded DNA breaks created by bacterial type IIA topoisomerases. Previous crystal structures of Staphylococcus aureus DNA gyrase with asymmetric DNAs have had static disorder (with the DNA duplex o...

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Gepubliceerd in:Acta Crystallogr F Struct Biol Commun
Hoofdauteurs: Srikannathasan, Velupillai, Wohlkonig, Alexandre, Shillings, Anthony, Singh, Onkar, Chan, Pan F., Huang, Jianzhong, Gwynn, Michael N., Fosberry, Andrew P., Homes, Paul, Hibbs, Martin, Theobald, Andrew J., Spitzfaden, Claus, Bax, Benjamin D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: International Union of Crystallography 2015
Onderwerpen:
Research Communications
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601586/
https://ncbi.nlm.nih.gov/pubmed/26457513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X15015290
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