Crystallization and initial crystallographic analysis of covalent DNA-cleavage complexes of Staphyloccocus aureus DNA gyrase with QPT-1, moxifloxacin and etoposide

Fluoroquinolone drugs such as moxifloxacin kill bacteria by stabilizing the normally transient double-stranded DNA breaks created by bacterial type IIA topoisomerases. Previous crystal structures of Staphylococcus aureus DNA gyrase with asymmetric DNAs have had static disorder (with the DNA duplex o...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Acta Crystallogr F Struct Biol Commun
Main Authors: Srikannathasan, Velupillai, Wohlkonig, Alexandre, Shillings, Anthony, Singh, Onkar, Chan, Pan F., Huang, Jianzhong, Gwynn, Michael N., Fosberry, Andrew P., Homes, Paul, Hibbs, Martin, Theobald, Andrew J., Spitzfaden, Claus, Bax, Benjamin D.
פורמט: Artigo
שפה:Inglês
יצא לאור: International Union of Crystallography 2015
נושאים:
Research Communications
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601586/
https://ncbi.nlm.nih.gov/pubmed/26457513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X15015290
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