Deficiency in the manganese efflux transporter SLC30A10 induces severe hypothyroidism in mice

Manganese is an essential metal that becomes toxic at elevated levels. Loss-of-function mutations in SLC30A10, a cell-surface-localized manganese efflux transporter, cause a heritable manganese metabolism disorder resulting in elevated manganese levels and parkinsonian-like movement deficits. The un...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Hutchens, Steven, Liu, Chunyi, Jursa, Thomas, Shawlot, William, Chaffee, Beth K., Yin, Weiling, Gore, Andrea C., Aschner, Michael, Smith, Donald R., Mukhopadhyay, Somshuvra
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5465498/
https://ncbi.nlm.nih.gov/pubmed/28461334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.783605
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