Immunoglobulin domain interface exchange as a platform technology for the generation of Fc heterodimers and bispecific antibodies

Bispecific antibodies (bsAbs) are of significant importance to the development of novel antibody-based therapies, and heavy chain (Hc) heterodimers represent a major class of bispecific drug candidates. Current technologies for the generation of Hc heterodimers are suboptimal and often suffer from c...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Skegro, Darko, Stutz, Cian, Ollier, Romain, Svensson, Emelie, Wassmann, Paul, Bourquin, Florence, Monney, Thierry, Gn, Sunitha, Blein, Stanislas
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5465497/
https://ncbi.nlm.nih.gov/pubmed/28450393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.782433
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