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Immunoglobulin domain interface exchange as a platform technology for the generation of Fc heterodimers and bispecific antibodies
Bispecific antibodies (bsAbs) are of significant importance to the development of novel antibody-based therapies, and heavy chain (Hc) heterodimers represent a major class of bispecific drug candidates. Current technologies for the generation of Hc heterodimers are suboptimal and often suffer from c...
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| Vydáno v: | J Biol Chem |
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| Hlavní autoři: | , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Biochemistry and Molecular Biology
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5465497/ https://ncbi.nlm.nih.gov/pubmed/28450393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.782433 |
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