Single-step Protein A and Protein G avidity purification methods to support bispecific antibody discovery and development

Heavy chain (Hc) heterodimers represent a majority of bispecific antibodies (bsAbs) under clinical development. Although recent technologies achieve high levels of Hc heterodimerization (HD), traces of homodimer contaminants are often present, and as a consequence robust purification techniques for...

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Dettagli Bibliografici
Pubblicato in:MAbs
Autori principali: Ollier, Romain, Wassmann, Paul, Monney, Thierry, Ries Fecourt, Christelle, Gn, Sunitha, C A, Vinu, Ayoub, Daniel, Stutz, Cian, Gudi, Girish S, Blein, Stanislas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2019
Soggetti:
Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6816383/
https://ncbi.nlm.nih.gov/pubmed/31462177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2019.1660564
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