Transgenic overexpression of GTP cyclohydrolase 1 in cardiomyocytes ameliorates post-infarction cardiac remodeling

GTP cyclohydrolase 1 (GCH1) and its product tetrahydrobiopterin play crucial roles in cardiovascular health and disease, yet the exact regulation and role of GCH1 in adverse cardiac remodeling after myocardial infarction are still enigmatic. Here we report that cardiac GCH1 is degraded in remodeled...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Liu, Yanan, Baumgardt, Shelley L., Fang, Juan, Shi, Yang, Qiao, Shigang, Bosnjak, Zeljko J., Vásquez-Vivar, Jeannette, Xia, Zhengyuan, Warltier, David C., Kersten, Judy R., Ge, Zhi-Dong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5465102/
https://ncbi.nlm.nih.gov/pubmed/28596578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03234-6
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