Cardiomyocyte GTP Cyclohydrolase 1 Protects the Heart Against Diabetic Cardiomyopathy

Diabetic cardiomyopathy increases the risk of heart failure and death. At present, there are no effective approaches to preventing its development in the clinic. Here we report that reduction of cardiac GTP cyclohydrolase 1 (GCH1) degradation by genetic and pharmacological approaches protects the he...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Wu, Hsiang-En, Baumgardt, Shelley L., Fang, Juan, Paterson, Mark, Liu, Yanan, Du, Jianhai, Shi, Yang, Qiao, Shigang, Bosnjak, Zeljko J., Warltier, David C., Kersten, Judy R., Ge, Zhi-Dong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4904741/
https://ncbi.nlm.nih.gov/pubmed/27295516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27925
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