Chronic Co-Administration of Sepiapterin and L-Citrulline Ameliorates Diabetic Cardiomyopathy and Myocardial Ischemia/Reperfusion Injury in Obese Type 2 Diabetic Mice

BACKGROUND: Diabetic heart disease is associated with tetrahydrobiopterin (BH(4)) oxidation and high arginase activity, leading to endothelial nitric oxide synthase (eNOS) dysfunction. Sepiapterin (SEP) is a BH(4) precursor, and L-citrulline (L-Cit) is converted to eNOS substrate, L-arginine. Whethe...

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Bibliografski detalji
Izdano u:Circ Heart Fail
Glavni autori: Baumgardt, Shelley L., Paterson, Mark, Leucker, Thorsten M., Fang, Juan, Zhang, David X., Bosnjak, Zeljko J., Warltier, David C., Kersten, Judy R., Ge, Zhi-Dong
Format: Artigo
Jezik:Inglês
Izdano: 2016
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4714787/
https://ncbi.nlm.nih.gov/pubmed/26763290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.115.002424
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