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Chronic Co-Administration of Sepiapterin and L-Citrulline Ameliorates Diabetic Cardiomyopathy and Myocardial Ischemia/Reperfusion Injury in Obese Type 2 Diabetic Mice
BACKGROUND: Diabetic heart disease is associated with tetrahydrobiopterin (BH(4)) oxidation and high arginase activity, leading to endothelial nitric oxide synthase (eNOS) dysfunction. Sepiapterin (SEP) is a BH(4) precursor, and L-citrulline (L-Cit) is converted to eNOS substrate, L-arginine. Whethe...
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| Publicado no: | Circ Heart Fail |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4714787/ https://ncbi.nlm.nih.gov/pubmed/26763290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.115.002424 |
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