Impairment of Endothelial-Myocardial Interaction Increases the Susceptibility of Cardiomyocytes to Ischemia/Reperfusion Injury

Endothelial-myocardial interactions may be critically important for ischemia/reperfusion injury. Tetrahydrobiopterin (BH(4)) is a required cofactor for nitric oxide (NO) production by endothelial NO synthase (eNOS). Hyperglycemia (HG) leads to significant increases in oxidative stress, oxidizing BH(...

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Detalhes bibliográficos
Main Authors: Leucker, Thorsten M., Ge, Zhi-Dong, Procknow, Jesse, Liu, Yanan, Shi, Yang, Bienengraeber, Martin, Warltier, David C., Kersten, Judy R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3718730/
https://ncbi.nlm.nih.gov/pubmed/23894596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0070088
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