Cardiac-specific overexpression of GTP cyclohydrolase 1 restores ischaemic preconditioning during hyperglycaemia

AIMS: Hyperglycaemia (HG) decreases intracellular tetrahydrobiopterin (BH(4)) concentrations, and this action may contribute to injury during myocardial ischaemia and reperfusion. We investigated whether increased BH(4) by cardiomyocyte-specific overexpression of the GTP cyclohydrolase (GTPCH) 1 gen...

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Détails bibliographiques
Auteurs principaux: Ge, Zhi-Dong, Ionova, Irina A., Vladic, Nikolina, Pravdic, Danijel, Hirata, Naoyuki, Vásquez-Vivar, Jeannette, Pratt, Phillip F., Warltier, David C., Pieper, Galen M., Kersten, Judy R.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2011
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Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3125073/
https://ncbi.nlm.nih.gov/pubmed/21422102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvr079
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