Identification and Functional Characterization of Phosphorylation Sites on GTP Cyclohydrolase I

OBJECTIVE: The post-translational regulation of GTP cyclohydrolase I (GCH-1), the rate-limiting enzyme for tetrahydrobiopterin (BH4) synthesis, remains elusive. Here, we identified specific phosphorylation sites on GCH-1 and characterized the function of these sites. METHODS AND RESULTS: Mass spectr...

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Detalhes bibliográficos
Main Authors: Du, Jianhai, Wei, Na, Xu, Hao, Ge, Ying, Vásquez-Vivar, Jeannette, Guan, Tongju, Oldham, Keith T., Pritchard, Kirkwood A., Shi, Yang
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798731/
https://ncbi.nlm.nih.gov/pubmed/19762783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.109.194464
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